SB02024 - CAS 2126737-28-6

SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity to Sunitinib and Erlotinib and that Vps34 is a promising therapeutic target for combination strategies in breast cancer.

STAT, Others, PI3K, CXCR

Immunology/Inflammation, JAK/STAT signaling, Autophagy, Others, PI3K/Akt/mTOR signaling, GPCR/G Protein, Stem Cells

2126703

C16H22F3N3O2

345.36

[C@](F)(F)(F)[C@@H]1N(CCCC1)C2=CC(=CC(=O)N2)N3[C@H](C)COCC3

-20°C

Ice Packs

Small Compound