SB1578 - CAS 937273-04-6

SB1578, also known as ONX-0805, is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.

Others

Others

937273-04-6

C26H30N4O4

462.54

O(CCN1CCCC1)C=2C3=CC(N=C4NC(C=5OC(=CC5)COC/C=C/COC3)=CC=N4)=CC2

-20°C

Ice Packs

Small Compound