SB334867 HCl - CAS 249889-64-3

SB-334867 (SB 334867A) is a potent, selective, and blood-brain barrier permeable antagonist of the orexin-1 (OX1) receptor, demonstrating significant selectivity against OX2 (pKb=7.4), and exhibiting 100-fold selectivity over 5-HT2B and 5-HT2C, with pKi values of 5.4 and 5.3, respectively [1]. This compound effectively reduces ethanol consumption and obstructs the development of morphine-induced sensitization to locomotor activity in vivo [2] [3].

OX Receptor

Neuroscience, GPCR/G Protein

249822

C17H14ClN5O2

355.78

Cl.Cc1nc2ccc(NC(=O)Nc3ccnc4cccnc34)cc2o1

-20°C

Ice Packs

Small Compound