SBI-0087702 - CAS 864431-36-7

SBI-0087702 enhances the cytoplasmic localization of ATF2 in melanoma cells. Induced translocation of ATF2 by SBI-0087702 to the mitochondria results in the loss of mitochondrial membrane integrity, thereby increasing apoptosis. Additionally, SBI-0087702 inhibits the growth and motility of melanoma cells. It also suppresses the phosphorylation of ATF2 at the Thr52 site by PKCε.

PKC

Chromatin/Epigenetic, Cytoskeletal Signaling

864388

C21H23NO2

321.413

O(C1=CC=C(C=C1)CCNCC2=CC=C(OC)C=3C=CC=CC32)C

-20°C

Ice Packs

Small Compound