SBI-0640726 - CAS 1321827-45-5

SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.

NF-κB, Akt, PERK

Cytoskeletal Signaling, Apoptosis, NF-κB, PI3K/Akt/mTOR signaling

1321827-45-5

C23H15ClN2O2

386.83

C(/C=C/C1=CC=CC=N1)(=O)C2=C(C=3C(NC2=O)=CC=C(Cl)C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound