SBI-810 hydrochloride - CAS 2772746-58-2

SBI-810 hydrochloride is a β-arrestin-2 (βarr2) -biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects through peripheral and central mechanisms by inhibiting excitatory synaptic transmission, suppressing NMDA receptor and ERK signalling in spinal nociceptive neurons, and reducing Nav1.7 expression and action potential discharge in primary sensory neurons.

Neurotensin Receptor, NMDAR, ERK, Sodium Channel

Membrane transporter/Ion channel, GPCR/G Protein, Neuroscience, MAPK

2772686

0.9942

C27H35ClN4O2

483.05

Cl.OCCN(C=1C=CC=2N=C(N=C(C2C1)N3CCC(C=4C=CC=CC4OC)CC3)C5(C)CC5)C

-20°C

Ice Packs

Small Compound