SC144 hydrochloride - CAS 917497-70-2

SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. Furthermore, SC144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].

Apoptosis, Interleukin, Others

Others, Immunology/Inflammation, Apoptosis

917425

C16H12ClFN6O

358.76

Cl.O=C(NNC1=NC=2C=C(F)C=CC2N3C=CC=C13)C4=NC=CN=C4

-20°C

Ice Packs

Small Compound