SC239 - CAS 1977557-97-3

SC239 is a 2-aminophenyl hemiasterlin-based agent-linker suitable for antibody-drug conjugate (ADC) applications. It features a tubulin-targeting warhead, SC209, connected through a cleavable valine-citrulline p-aminobenzyl carbamate linker equipped with dibenzocyclooctyne (DBCO) . This drug-linker displays enhanced cytotoxic activity in Igrov1 cells with lower FolRα expression levels.

Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related

1977457

C65H84N10O11

1181.42

C(CCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(NC2=CC(C([C@@H](C(N[C@H](C(N([C@H](/C=C(/C(O)=O)\C)C(C)C)C)=O)[C@](C)(C)C)=O)NC)(C)C)=CC=C2)=O)C=C1)=O)CCCNC(N)=O)=O)C(C)C)=O)(=O)N3C=4C(C#CC=5C(C3)=CC=CC5)=CC=CC4

-20°C

Ice Packs

Small Compound