SCAL-255 - CAS 2798953-61-2

SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP) . Furthermore, SCAL-255 significantly hampers the proliferation of cancer cells reliant on oxidative phosphorylation (OXPHOS) [1].

OXPHOS, Mitochondrial Metabolism

Apoptosis, Metabolism

2798890

C27H28F3N5O3

527.54

C(C=1C=C(N2CCN(C(=O)C3CC3)CC2)C=CC1)N4N=C(C(NC5=CC=C(OC(F)(F)F)C=C5)=O)C=C4C

-20°C

Ice Packs

Small Compound