SCAL-266 - CAS 2798953-78-1

SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP) . Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].

OXPHOS, Mitochondrial Metabolism

Metabolism, Apoptosis

2798874

C27H28F3N5O2

511.54

C(C=1C=C(C=CC1)N2CCN(C(=O)C3CC3)CC2)N4N=C(C(NC5=CC=C(C(F)(F)F)C=C5)=O)C=C4C

-20°C

Ice Packs

Small Compound