SCH-37370 - CAS 117796-52-8

SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM) .

Histamine Receptor, PAFR, Platelet aggregation

Others, GPCR/G Protein, Neuroscience, Immunology/Inflammation

117796-52-8

0.9992

C21H21ClN2O

352.86

ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(C)=O)CC4)=CC1

-20°C

Ice Packs

Small Compound