SCH-42354 - CAS 144505-58-8

SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic peptide (ANP) and prevents the hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. Furthermore, SCH-42354 exhibits antihypertensive activity [1] [2].

Neprilysin, Others

Others, Metabolism

144439

C16H23NO3S2

341.49

C([C@@H](C(N[C@@H](CCSC)C(O)=O)=O)CS)C1=C(C)C=CC=C1

-20°C

Ice Packs

Small Compound