SDH-IN-25 - CAS 3052432-15-9

SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.

Reactive Oxygen Species, MMP, Antifungal

Microbiology/Virology, Metabolism, Proteases/Proteasome, Immunology/Inflammation, NF-κB

3052408

C19H15BrCl2N2O4

486.143

O=C1OC(C=2C=C(Cl)C=C(Cl)C2OCC(=O)NNC3=CC=C(Br)C=C3)CC1=C

-20°C

Ice Packs

Small Compound