Secalonic acid D - CAS 35287-69-5

Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc expression, arresting the cell cycle at the G1 phase, and inducing cell apoptosis [1] [2].

C-Myc, Apoptosis, GSK-3, Others, Wnt/beta-catenin

Others, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Stem Cells, Cytoskeletal Signaling, Apoptosis

35213

C32H30O14

638.57

C(OC)(=O)[C@]12C(C(=O)C=3C(O1)=CC=C(C3O)C=4C(O)=C5C(=CC4)O[C@]6(C(OC)=O)C(C5=O)=C(O)C[C@H](C)[C@H]6O)=C(O)C[C@H](C)[C@H]2O

-20°C

Ice Packs

Natural Product