Seco-DUBA - CAS 1227961-59-2

Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC) . It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.

DNA Alkylation, ADC Cytotoxin

DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related

1227900

0.9981

C29H23ClN4O4

526.97

C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6

-20°C

Ice Packs

Small Compound