γ-Secretase modulator 11 - CAS 2434630-29-0

5-{8-[ (3,4'-Difluoro[1,1'-biphenyl]-4-yl) methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, significantly reduced brain Aβ42 levels, showed no inhibitory effect on cytochrome p450 enzymes, and demonstrated excellent anti-cognitive deficits in AD model mice.

Others, Gamma-secretase

Neuroscience, Proteases/Proteasome, Others, Stem Cells

2434601

C28H22F2N4O2

484.5

CC1=C(N2C(C(OCC3=C(F)C=C(C=C3)C4=CC=C(F)C=C4)=CC=C2)=N1)C=5C=CC(C(NC)=O)=NC5

-20°C

Ice Packs

Small Compound