γ-Secretase modulator 12 - CAS 2204249-82-9

γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].

Beta Amyloid, Gamma-secretase, Others

Others, Proteases/Proteasome, Neuroscience, Stem Cells

2204158

C25H23N3O2

397.47

CC1=C(N2C(C(OCC3=CC=CC=C3)=CC=C2)=N1)C=4C=C5C(=CC4)C(=O)N(CC)C5

-20°C

Ice Packs

Small Compound