Selaginellin - CAS 941269-84-7

Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows inhibitory effect on high glucose-induced cell injury and apoptosis in differentiated PC12 cells, which is related to inhibition of LOX-1/NADPH oxidase-reactive oxygen species/caspase-3 signaling pathway.

Sirtuin, Reactive Oxygen Species

NF-κB, Immunology/Inflammation, Chromatin/Epigenetic, Metabolism, DNA Damage/DNA Repair

941178

C34H24O5

512.55

O=C1C=CC(C=C1)=C(C2=CC=C(O)C=C2)C3=C(C#CC4=CC=C(O)C=C4)C(=CC=C3C=5C=CC(O)=CC5)CO

-20°C

Ice Packs

Natural Product