Semapimod tetrahydrochloride - CAS 164301-51-3

Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.

MAPK, p38 MAPK, TLR, Interleukin, TNF

Immunology/Inflammation, MAPK, Apoptosis

164247

0.998

C34H56Cl4N18O2

890.74

Cl.Cl.Cl.Cl.C\C(=N/NC(N)=N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(cc(c2)C(\C)=N\NC(N)=N)C(\C)=N\NC(N)=N)cc(c1)C(\C)=N\NC(N)=N

-20°C

Ice Packs

Small Compound