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Molfinity

Semaxinib - CAS 204005-46-9

Semaxinib - CAS 204005-46-9

MF-0019327-01

$42.89 USD
$42.89 USD
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Product Details

  • Bioactivity

    Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.

  • Target

    VEGFR

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors

  • CAS Number

    203950

  • Purity

    0.9984

  • Molecular Formula

    C15H14N2O

  • Molecular Weight

    238.28

  • SMILES

    C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound