Senexin A hydrochloride - CAS 1780390-76-2

Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].

CDK, Others

Others, Cell Cycle/Checkpoint

1780390-76-2

C17H15ClN4

310.78

N(CCC1=CC=CC=C1)C=2C3=C(C=CC(C#N)=C3)N=CN2.Cl

-20°C

Ice Packs

Small Compound