1 1

Molfinity

Senicapoc - CAS 289656-45-7

Senicapoc - CAS 289656-45-7

MF-0016574-01

$33.92 USD
$33.92 USD
Sale Sold out
Taxes included.
Size
View full details

Product Details

  • Bioactivity

    Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.

  • Target

    Potassium Channel

  • Related Pathways

    Membrane transporter/Ion channel

  • CAS Number

    289604

  • Purity

    0.995

  • Molecular Formula

    C20H15F2NO

  • Molecular Weight

    323.34

  • SMILES

    NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound