Sesaminol - CAS 74061-79-3

Sesaminol is an orally active activator of the Nrf2-ARE signaling pathway, promoting the nuclear translocation of Nrf2 and boosting the expression of NQO1 to enhance cellular defense against oxidative stress. It inhibits 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Sesaminol also provides neuroprotective effects against Rotenone-induced Parkinson's disease.

Nrf2, Reactive Oxygen Species

Metabolism, NF-κB, Immunology/Inflammation

73979

C20H18O7

370.35

OC1=C([C@@H]2[C@@]3([C@@]([C@H](OC3)C=4C=C5C(=CC4)OCO5)(CO2)[H])[H])C=C6C(=C1)OCO6

-20°C

Ice Packs

Small Compound