SET-171 - CAS 3052985-32-4

SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity by suppressing the expression of hepatic pyruvate kinase (PKL) and offers potential in regulating lipid metabolism. In antitumor studies, SET-171 shows notable cytotoxicity against human liver cancer cell lines HepG2 and Huh7, with IC50 values of 8.82 μM and 2.97 μM, respectively. Additionally, in research related to non-alcoholic fatty liver disease (NAFLD), SET-171 significantly reduces triglyceride (TAG) levels and inhibits the expression of proteins associated with steatosis. This compound holds promise for hepatocellular carcinoma (HCC) and NAFLD research.

JNK, PKM

MAPK, Metabolism

3052949

C27H21BrN4O2S

545.45

N#CC1=C(SC2=C1CCN(CC(=O)NC=3C=CC=C(Br)C3)C2)NC(=O)C4=CC=CC=5C=CC=CC54

-20°C

Ice Packs

Small Compound