Setipiprant - CAS 866460-33-5

Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM) . CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release.

Prostaglandin Receptor, GPCR

GPCR/G Protein, Immunology/Inflammation, Endocrinology/Hormones

866460-33-5

0.9971

C24H19FN2O3

402.42

C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2

-20°C

Ice Packs

Small Compound