SEW2871 - CAS 256414-75-2

SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.

LPL Receptor, S1P Receptor, ERK, Akt

MAPK, GPCR/G Protein, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling

256337

0.9996

C20H10F6N2OS

440.36

FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F

-20°C

Ice Packs

Small Compound