SF-9-2 - CAS 3053768-78-5

SF-9-2 is a PD-L1/PD-1 binding inhibitor with an IC50 of 24.9 nM. It suppresses epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, while also inducing apoptosis and causing cell cycle arrest. SF-9-2 blocks PD-L1-induced growth of SK-N-SH cells via the MAPK signaling pathway. It restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. In the SK-N-SH NOG mouse model, SF-9-2 inhibits tumor growth without notable toxicity. Additionally, SF-9-2 acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function and is applicable to neuroblastoma research.

PD-1/PD-L1, ERK, JNK, GSK-3, Cadherin, Bcl-2 Family, Caspase, p38 MAPK, Apoptosis, IFNAR

Cytoskeletal Signaling, Cell Cycle/Checkpoint, MAPK, PI3K/Akt/mTOR signaling, Immunology/Inflammation, Proteases/Proteasome, Apoptosis, Stem Cells

3053685

C30H27F2N3O3

515.55

N#CC1=CN=CC(=C1)COC2=CC(OCC3=CC=CC(C=4C=CC=CC4F)=C3CF)=CC=C2CNCCO

-20°C

Ice Packs

Small Compound