SHP2/HDAC-IN-1 - CAS 2831230-38-5

SHP2/HDAC-IN-1, a dual allosteric inhibitor targeting SHP2 and HDAC, exhibits potent inhibitory effects with IC 50 values of 20.4 nM (SHP2) and 25.3 nM (HDAC1), respectively. This compound activates T cells, enhances antigen presentation, and promotes cytokine secretion, facilitating efficient antitumor immunity. It holds potential for cancer immunotherapy research.

Others, Phosphatase, HDAC

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism

2831187

C34H35Cl2N7O3

660.59

ClC1=C(C=CC=C1Cl)C=2C(N)=NC(=CN2)N3CCC(NCC4=CC=C(C(NCC5=CC=C(/C=C/C(NO)=O)C=C5)=O)C=C4)(C)CC3

-20°C

Ice Packs

Small Compound