SHP2-IN-23 - CAS 2415989-91-0

SHP2-IN-23 (compound 30) is an orally active inhibitor of SHP2, exhibiting potent activity with an IC50 value of 38 nM and demonstrating favorable pharmacokinetic profiles and in vivo efficacy. Additionally, it robustly inhibits ERK phosphorylation, achieving an IC50 of 5 nM [1].

ERK, Phosphatase

Metabolism, MAPK

2415989-91-0

C24H23ClN8S

491.01

N[C@H]1C2(CC=3C1=CC=CN3)CCN(CC2)C4=NC5=C(N=C4)N=C(SC=6C(Cl)=C(N)N=CC6)C=C5

-20°C

Ice Packs

Small Compound