SHP2-IN-31 - CAS 2411321-35-0

SHP2-IN-31 is an SHP2 inhibitor with an IC50 value of 13 nM (wild-type SHP2), >10000 nM (SHP1), and >10000 nM (SHP2 E76K) . This compound effectively inhibits pERK in a variety of tumor cells and suppresses tumor growth in xenograft models driven by RTK/KRAS.

Ras, Kras

MAPK

2411321-35-0

C21H26Cl2N4O2

437.36

N[C@H]1C2(CCN(CC2)C3=C(C)C(=O)N(C(C)=N3)C4=C(Cl)C(Cl)=CC=C4)CO[C@H]1C

-20°C

Ice Packs

Small Compound