SHP2-IN-8 - CAS 1801692-60-3

SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement (Δ Tm = 7.01 °C) . SHP2-IN-8 can inhibit the phosphorylation of AKT and induce apoptosis of Hela cells.

Others, Phosphatase, Apoptosis, Akt

Cytoskeletal Signaling, Metabolism, Others, Apoptosis, PI3K/Akt/mTOR signaling

1801629

C17H21Cl2N5S

398.35

NC=1N=C(N2CCC(CN)(C)CC2)C=NC1SC3=C(Cl)C(Cl)=CC=C3

-20°C

Ice Packs

Small Compound