SHR902275 - CAS 2695506-82-0

SHR902275 is a selective, potent, orally active RAF inhibitor targeting RAS mutant cancers, acting on cRAF (IC50: 1.6 nM), bRAFwt (IC50: 10 nM), and bRAFV600E (IC50: 5.7 nM) . SHR902275 exhibits cell growth inhibitory effects in H358 cells (GI50: 1.5 nM), A375 cells (GI50: 0.17 nM), Calu6 cells (GI50: 0.4 nM), and SK-MEL2 cells (GI50: 0.32 nM) .

Raf, Others

Others, MAPK

2695424

C26H23F3N4O4

512.48

O=C1CC2(OC=3C(N1)=CC=C(C3)C4=CC(NC(=O)C5=CC(C(F)(F)F)=CN=N5)=CC=C4C)CCOCC2

-20°C

Ice Packs

Small Compound