SHS4121705 - CAS 2379550-82-8

SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH) .

Others, Mitochondrial Metabolism

Others, Metabolism

2379460

C11H6F3N5O3

313.19

N(C1=NC=2C(=NC1=O)NON2)C3=CC=C(OC(F)(F)F)C=C3

-20°C

Ice Packs

Small Compound