SIAIS178 - CAS 2376047-73-1

SIAIS178 is a selective PROTAC degrader targeting BCR-ABL with an IC50 of 24 nM. It degrades BCR-ABL protein by recruiting the VHL E3 ubiquitin ligase, inhibiting leukaemia cell growth in vitro and causing regression of K562 xenograft tumours.

PROTACs, Ligand for E3 Ligase, Bcr-Abl

Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, PROTAC

2375973

0.9807

C50H62ClN11O6S2

1012.68

C([C@@H](NC(CCCCCCC(=O)N1CCN(CC1)C=2C=C(NC=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3)N=C(C)N2)=O)[C@](C)(C)C)(=O)N5[C@H](C(NCC6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5

-20°C

Ice Packs

PROTAC