Sigma-1 receptor antagonist 6 - CAS 1335032-28-4

Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R) . This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.

Sigma receptor

GPCR/G Protein

1335032-28-4

C32H34N6

502.65

N#CC1=C(N=C(C(C#N)=C1C=2C=CC=CC2)N(C)CC#C)NCCCC3CCN(CC=4C=CC=CC4)CC3

-20°C

Ice Packs

Small Compound