SIK-IN-1 - CAS 3033846-29-3

SIK-IN-1 (Compound 53) acts as a potent inhibitor of salt-inducible kinase (SIK), specifically targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.4, and 1.5 nM, respectively. Additionally, it effectively suppresses TNFa release with an IC50 of 0.5 nM and enhances LPS-induced IL-10 release in human macrophages with an EC50 of 4 nM [1].

AMPK

Chromatin/Epigenetic, PI3K/Akt/mTOR signaling

3033846-29-3

C23H24N6OS

432.54

C(#N)C=1N2C(=CN=C2C=CC1NC)C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3

-20°C

Ice Packs

Small Compound