SIK2-IN-3 - CAS 2810809-10-8

SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.

SIK

PI3K/Akt/mTOR signaling

2810791

C23H24N6O2

416.48

O(C[C@@H]1CCN(C)C1)C=2C(=CC(C#N)=NC2)C3=CC=4N(C=C3)N=C(NC(=O)C5CC5)C4

-20°C

Ice Packs

Small Compound