SIKs-IN-1 - CAS 2927557-06-8

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases anti-inflammatory cytokine IL-10 and decreases pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].

Others, SIK

PI3K/Akt/mTOR signaling, Others

2927557-06-8

C27H31F2N7O

507.58

C(NC1=C(C)C=CC=C1F)(=O)C=2C(NC3CCC3)=NC(NC4=CC(F)=C(C=C4)N5CCN(C)CC5)=NC2

-20°C

Ice Packs

Small Compound