SILA-123 - CAS 2911585-37-8

SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.

Apoptosis, FLT

Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis

2911540

C24H25N5O2

415.49

O=C(NC=1C=CC(=CC1)C=2C=C(N=C3ON=C(N)C32)C)NC4=CC=C(C=C4)C(C)(C)C

-20°C

Ice Packs

Small Compound