Simmiparib - CAS 1551355-46-4

Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR) -deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.

Apoptosis, PARP

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

1551305

0.9951

C23H18F4N6O2

486.42

CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F

-20°C

Ice Packs

Small Compound