Simufilam dihydrochloride - CAS 2480226-06-8

Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.

Beta Amyloid, AChR, mTOR, Others, Microtubule Associated, iGluR

PI3K/Akt/mTOR signaling, Others, Neuroscience, Membrane transporter/Ion channel, Cytoskeletal Signaling

2480226-06-8

0.9972

C15H23Cl2N3O

332.3

[H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl

-20°C

Ice Packs

Small Compound