Simufilam hydrochloride - CAS 2480226-07-9

Simufilam (PTI-125) (hydrochloride) is an orally active filamin A (FLNA) activator with low toxicity that can be used in the Alzheimer's disease research. Simufilam (hydrochloride) preferentially binds to altered FLNA and restores its native conformation, restores receptor and synaptic activities, and reduces its a7nAChR/TLR4 associations and downstream pathologies [1].

Others, Microtubule Associated, Beta Amyloid, mTOR, iGluR

Membrane transporter/Ion channel, Cytoskeletal Signaling, Neuroscience, Others, PI3K/Akt/mTOR signaling

2480226-07-9

C15H22ClN3O

295.81

Cl.CN1CCC2(CC1)NCC(=O)N2Cc1ccccc1

-20°C

Ice Packs

Small Compound