Siramesine - CAS 147817-50-3

Siramesine (Lu 28-179) (Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost

Sigma receptor

GPCR/G Protein

147764

C30H31FN2O

454.58

C(CCCC=1C=2C(N(C1)C3=CC=C(F)C=C3)=CC=CC2)N4CCC5(C=6C(CO5)=CC=CC6)CC4

-20°C

Ice Packs

Small Compound