SIRT-IN-7 - CAS 1620634-65-2

SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. It effectively suppresses the expression of SIRT1, SIRT2, and SIRT3, leading to increased acetylation and activation of p53. Additionally, SIRT-IN-7 inhibits the proliferation of breast cancer cells and induces apoptosis and autophagy, demonstrating antitumor activity.

Apoptosis, MDM-2/p53, Autophagy, Sirtuin

Chromatin/Epigenetic, Apoptosis, Autophagy, DNA Damage/DNA Repair

1620567

C24H16BrClN2OS

495.819

ClC=1C=CC=2N=C(SC2C1)NC(C3=CC=C(Br)C=C3)C4=C(O)C=CC=5C=CC=CC54

-20°C

Ice Packs

Small Compound