Sirt1/2-IN-2 - CAS 670267-73-9

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1].

Apoptosis, Sirtuin

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

670185

C18H14N4O3S2

398.46

N(S(=O)(=O)C1=CC=CC=C1)C=2C3=C(C(O)=C(SC=4NC=NN4)C2)C=CC=C3

-20°C

Ice Packs

Small Compound