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Molfinity

SIRT2-IN-11 - CAS 1005095-06-6

SIRT2-IN-11 - CAS 1005095-06-6

MF-0146469-01

$988.92 USD
$988.92 USD
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Product Details

  • Bioactivity

    SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.

  • Target

    Others, Sirtuin

  • Related Pathways

    Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

  • CAS Number

    1005095-06-6

  • Molecular Formula

    C21H22N2O

  • Molecular Weight

    318.41

  • SMILES

    C(N)(=O)C=1C=C2C3C(C(NC2=CC1)C4=CC=CC=C4)C5CC3CC5

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound