SIRT5 inhibitor 7 - CAS 2951090-00-7

SIRT5 inhibitor 7 (compound 58), a substrate-competitive and selective SIRT5 inhibitor with IC 50 = 310 nM, significantly attenuated renal dysfunction and pathological damage in lipopolysaccharide (LPS) - and cecum ligation/perforation (CLP) -induced septic AKI mice, and modulated proteinsuccinimidylation and proinflammatory cytokine release and pro-inflammatory cytokine release in the kidneys of acute kidney injury (AKI) mice.

Sirtuin

Chromatin/Epigenetic, DNA Damage/DNA Repair

2951090-00-7

0.9977

C28H32ClN7O3S

582.12

N(CCCNC(NCCC(O)=O)=S)C=1C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)=CN=C(NC4=C(Cl)C=CC=C4)N1

-20°C

Ice Packs

Small Compound