SIRT6 activator 12q - CAS 2601734-99-8

SIRT6 activator 12q is a potent, selective, and orally active compound that activates SIRT6. It demonstrates IC50 values of 171.20 μM for SIRT1, >200 μM for SIRT2, SIRT3, and SIRT5, and 0.58 μM for SIRT6, indicating its high specificity towards SIRT6. This compound effectively inhibits cell growth and migration, induces apoptosis, and causes cell cycle arrest at the G2 phase, showcasing its anticancer activity.

Apoptosis, Sirtuin, Others

Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair, Others

2601627

C31H22N2O2

454.52

C(NC(C1=CC=CC=C1)C2=CC=CC=C2)(=O)C=3C4=C(N=C(C3)C5=CC=6C(O5)=CC=CC6)C=CC=C4

-20°C

Ice Packs

Small Compound