SIRT6-IN-3 - CAS 3023471-40-8

SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].

Sirtuin

DNA Damage/DNA Repair, Chromatin/Epigenetic

3023423

C21H30Br3ClN6S

673.73

[Br-].Cl.BrC=1C=C(NC1Br)C2=NC=CC3=C2N=CN3CCCCCCSC(N(C)C)=[N+](C)C

-20°C

Ice Packs

Small Compound