Sitamaquine hydrochloride - CAS 5330-29-0

Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.

Parasite, Histamine Receptor, Mitochondrial Metabolism

Immunology/Inflammation, Neuroscience, Microbiology/Virology, GPCR/G Protein, Metabolism

5301

C21H35Cl2N3O

416.43

COC1=CC2=C(C)C=CN=C2C(NCCCCCCN(CC)CC)=C1.Cl.Cl

-20°C

Ice Packs

Small Compound